The past 2 years have been a strange and difficult time for the world. The COVID-19 pandemic has brought illness, hospitalization, and death near to many people. In the United States, people are divided not only on what they should do but also on what constitutes the facts. Many are seemingly in an alternative world, driven by disinformation, conspiracy theories, and anti-science beliefs. How can health and medical leaders do their jobs while trying to cope with a polarized public? They must be more effective in explaining and persuading the public on matters of science and health. This will require better clarification of two things to the public—the roles of science and politics in public policy decisions, and the means by which scientific truth is established and updated.