Broad betacoronavirus neutralization by a stem helix–specific human antibody
Copyright policy )Broad betacoronavirus neutralization by a stem helix–specific human antibody
Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike protein that decorates these viruses has an S1 domain that binds host cell receptors and an S2 domain that fuses the viral and cell membranes to allow cell entry. The S1 domain is the target of many neutralizing antibodies but is more genetically variable than S2, and antibodies can exert selective pressure, leading to resistant variants. Pinto et al . identified five monoclonal antibodies that interact with a helix in the S2 domain. The most broadly neutralizing antibody inhibited all β-coronavirus subgenera and reduced viral burden in hamsters infected with SARS-CoV-2. —VV
- University of Washington United States
- ETH Zurich Switzerland
- Institute of Microbiology Switzerland
- University of Zurich Switzerland
- Luigi Sacco Hospital Italy
Protein Conformation, alpha-Helical, Coronaviruses, Protein Conformation, 3207 Medical Microbiology, PROTEIN, ACE2, 32 Biomedical and Clinical Sciences, Membrane Fusion, Jurkat Cells, DOMAIN, NANOPARTICLE VACCINES, Cricetinae, Monoclonal, INFECTION, anzsrc-for: 31 Biological Sciences, Neutralizing, Lung, Research Articles, anzsrc-for: 3204 Immunology, Antibodies, Monoclonal, 3 Good Health and Well Being, Viral Load, Spike Glycoprotein, Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Betacoronavirus; Convalescence; Cricetinae; Cross Reactions; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Jurkat Cells; Lung; Membrane Fusion; Neutralization Tests; Peptide Mapping; Protein Conformation, alpha-Helical; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Viral Load; Viral Vaccines; Virus Internalization, 3204 Immunology, Multidisciplinary Sciences, Infectious Diseases, Spike Glycoprotein, Coronavirus, Science & Technology - Other Topics, CORONAVIRUS SPIKE GLYCOPROTEIN, Infection, Biotechnology, 570, General Science & Technology, 1.1 Normal biological development and functioning, 610, SARS-COV-2, Cross Reactions, Peptide Mapping, Antibodies, Vaccine Related, Betacoronavirus, Immunoglobulin Fab Fragments, anzsrc-for: 32 Biomedical and Clinical Sciences, Neutralization Tests, Animals, Humans, anzsrc-for: 3207 Medical Microbiology, Science & Technology, 5.2 Cellular and gene therapies, IDENTIFICATION, MUTATIONS, SARS-CoV-2, Prevention, alpha-Helical, Convalescence, Viral Vaccines, Virus Internalization, Antibodies, Neutralizing, Immunoglobulin Fc Fragments, Coronavirus, Emerging Infectious Diseases, Immunization, 31 Biological Sciences, RESPONSES
Protein Conformation, alpha-Helical, Coronaviruses, Protein Conformation, 3207 Medical Microbiology, PROTEIN, ACE2, 32 Biomedical and Clinical Sciences, Membrane Fusion, Jurkat Cells, DOMAIN, NANOPARTICLE VACCINES, Cricetinae, Monoclonal, INFECTION, anzsrc-for: 31 Biological Sciences, Neutralizing, Lung, Research Articles, anzsrc-for: 3204 Immunology, Antibodies, Monoclonal, 3 Good Health and Well Being, Viral Load, Spike Glycoprotein, Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Betacoronavirus; Convalescence; Cricetinae; Cross Reactions; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Jurkat Cells; Lung; Membrane Fusion; Neutralization Tests; Peptide Mapping; Protein Conformation, alpha-Helical; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Viral Load; Viral Vaccines; Virus Internalization, 3204 Immunology, Multidisciplinary Sciences, Infectious Diseases, Spike Glycoprotein, Coronavirus, Science & Technology - Other Topics, CORONAVIRUS SPIKE GLYCOPROTEIN, Infection, Biotechnology, 570, General Science & Technology, 1.1 Normal biological development and functioning, 610, SARS-COV-2, Cross Reactions, Peptide Mapping, Antibodies, Vaccine Related, Betacoronavirus, Immunoglobulin Fab Fragments, anzsrc-for: 32 Biomedical and Clinical Sciences, Neutralization Tests, Animals, Humans, anzsrc-for: 3207 Medical Microbiology, Science & Technology, 5.2 Cellular and gene therapies, IDENTIFICATION, MUTATIONS, SARS-CoV-2, Prevention, alpha-Helical, Convalescence, Viral Vaccines, Virus Internalization, Antibodies, Neutralizing, Immunoglobulin Fc Fragments, Coronavirus, Emerging Infectious Diseases, Immunization, 31 Biological Sciences, RESPONSES
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).342 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!