Development of an inactivated vaccine candidate for SARS-CoV-2
Copyright policy )Development of an inactivated vaccine candidate for SARS-CoV-2
Vaccine candidate tested in monkeys Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent race to develop a vaccine. Gao et al. report preclinical results of an early vaccine candidate called PiCoVacc, which protected rhesus macaque monkeys against SARS-CoV-2 infection when analyzed in short-term studies. The researchers obtained multiple SARS-CoV-2 strains from 11 hospitalized patients across the world and then chemically inactivated the harmful properties of the virus. Animals were immunized with one of two vaccine doses and then inoculated with SARS-CoV-2. Those that received the lowest dose showed signs of controlling the infection, and those receiving the highest dose appeared more protected and did not have detectable viral loads in the pharynx or lungs at 7 days after infection. The next steps will be testing for safety and efficacy in humans. Science , this issue p. 77
- Institute of Biophysics China (People's Republic of)
- Centers for Disease Control and Prevention United States
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Sinovac Biotech China (People's Republic of)
- Academy of Military Medical Sciences China (People's Republic of)
Male, Pilot Projects, Infectious disease (medical specialty), FOS: Health sciences, Antibodies, Viral, Coronavirus Disease 2019, Mice, Immunogenicity, Vaccine, Chlorocebus aethiops, Disease, Internal medicine, Mice, Inbred BALB C, Vaccines, Multidisciplinary, Virus, Infectious Diseases, Medicine, Female, Coronavirus Infections, Macaque, COVID-19 Vaccines, Pneumonia, Viral, Immunology, Dose-Response Relationship, Immunologic, Coronavirus Disease 2019 Research, Betacoronavirus, Inoculation, Virology, Health Sciences, Animals, Pandemics, Biology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), FOS: Clinical medicine, COVID-19, Gastrointestinal Viral Infections and Vaccines Development, Paleontology, Antibodies, Neutralizing, Macaca mulatta, Rats, Coronavirus disease 2019 (COVID-19), Immunoglobulin G, Pharynx, Surgery, Reports
Male, Pilot Projects, Infectious disease (medical specialty), FOS: Health sciences, Antibodies, Viral, Coronavirus Disease 2019, Mice, Immunogenicity, Vaccine, Chlorocebus aethiops, Disease, Internal medicine, Mice, Inbred BALB C, Vaccines, Multidisciplinary, Virus, Infectious Diseases, Medicine, Female, Coronavirus Infections, Macaque, COVID-19 Vaccines, Pneumonia, Viral, Immunology, Dose-Response Relationship, Immunologic, Coronavirus Disease 2019 Research, Betacoronavirus, Inoculation, Virology, Health Sciences, Animals, Pandemics, Biology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), FOS: Clinical medicine, COVID-19, Gastrointestinal Viral Infections and Vaccines Development, Paleontology, Antibodies, Neutralizing, Macaca mulatta, Rats, Coronavirus disease 2019 (COVID-19), Immunoglobulin G, Pharynx, Surgery, Reports
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