South Asian countries are often at odds with each other for political, economic, and emotional reasons. The conflicts are a frustrating contrast to the promise of the region. Covering only 3.5% of Earth's landmass, but inhabited by 23.7% of humanity, the region has the highest rate of economic growth, is rich in knowledge-based institutions, and is home to many indigenous and technological innovations. Sadly, at the same time, South Asian countries have the highest poverty rate, lowest human development index (except for sub-Saharan Africa), the most polluted air, the greatest burden of diseases, and increased vulnerability to climate change. It's time to reinvent science diplomacy in this part of the world to spur collaborations that can help resolve conflicts that are preventing South Asia from achieving its potential.