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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Sciencearrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Science
Article . 2018
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No conflict of interest in data monitoring

Authors: Jonathan L, Halperin;

No conflict of interest in data monitoring

Abstract

The News Feature “Hidden conflicts?” (C. Piller, 6 July, p. [16][1]) alleges that after serving as a member of a Food and Drug Administration (FDA) advisory panel for a nominal per diem payment, I later received inappropriate payments from the manufacturer (AstraZeneca) for serving on and chairing data monitoring committees (DMCs) overseeing AstraZeneca-sponsored research. Those assertions are inaccurate. The universities conducting clinical trials, not AstraZeneca, compensated DMC members for their time. More important, the OpenPayments database still reports inaccurate payments far in excess of the amount I received from the university. AstraZeneca has acknowledged that it mistakenly reported my name and attributed inaccurate amounts to me in its filing to the database and has agreed to correct these errors. Serving on a DMC does not involve conducting research, and I did not conduct research on any drug for AstraZeneca after serving on the FDA panel. The DMCs on which I served oversaw the safety of participants enrolled in two postapproval trials funded through research contracts with academic institutions, not contracts with AstraZeneca. Members of DMCs are required to act independently of trial sponsors; they are not investigators. Their responsibility is to ensure the safety of trial participants and scientific integrity of studies to advance research. In this case, the outcomes of both trials were unfavorable to AstraZeneca. Regardless of the outcome, however, I had no financial relationship with the company; the fees, which were nominal, came to me through the university. Serving on a DMC is not a conflict of interest but a public service. My role was to protect the interests of patients, science, and the public. [1]: http://www.sciencemag.org/content/361/6397/16

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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