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Parallel adaptation of rabbit populations to myxoma virus

descriptionPublicationkeyboard_double_arrow_right Article 22 Mar 2019Embargo end date: 13 Feb 2019 United Kingdom, United States, Australia, Denmark English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 363, pages 1,319-1,326 (issn: 0036-8075, eissn: 1095-9203, Copyright policy )Funded by:EC | DROSOPHILAINFECTION, WT | Molecular mechanisms of m..., EC | LocalAdaptation +3 projects
Authors: Alves, Joel M.; Carneiro, Miguel; Cheng, Jade Y.; Lemos de Matos, Ana; Rahman, Masmudur M.; Loog, Liisa; Campos, Paula F.; +21 Authors

doi: 10.1126/science.aau7285 , 10.17863/cam.36606

pmid: 30765607

pmc: PMC6433279

Parallel adaptation of rabbit populations to myxoma virus

Abstract

Locating myxomatosis resistance Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have emerged in parallel in the United Kingdom, France, and Australia. Alves et al. discovered that the basis for this resistance is polygenic, with selection converging on several host immunity and proviral alleles (see the Perspective by Miller and Metcalf). Interestingly, it now seems that the virus is counterevolving immune suppressive traits. Science , this issue p. 1319 ; see also p. 1277

Countries
United Kingdom, United States, Australia, Denmark
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Keywords

570, 1000, General Science & Technology, Evolution, Population, Adaptation, Biological, Interferon alpha-2, Polymorphism, Single Nucleotide, Vaccine Related, Evolution, Molecular, Gene Frequency, Myxomatosis, Infectious, Biodefense, Genetics, Innate, Animals, Adaptation, Polymorphism, Alleles, Prevention, Immunity, Infectious, Australia, Myxoma virus, Molecular, Genetic Variation, Single Nucleotide, Biological, Immunity, Innate, United Kingdom, Emerging Infectious Diseases, Myxomatosis, France, Rabbits, Infection

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 146
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
146
Top 1%
Top 10%
Top 1%
Green
bronze
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