The opium poppy genome and morphinan production

descriptionPublicationkeyboard_double_arrow_right Article 19 Oct 2018 United Kingdom English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 362, pages 343-347 (issn: 0036-8075, eissn: 1095-9203,

Copyright policy )Funded by:UKRI | Understanding the regulat..., WT | Wellcome Trust Sanger Ins..., WT | unidentified

Authors: Li Guo; Thilo Winzer; Xiaofei Yang; Yi Li; Zemin Ning; Zhesi He; Roxana Teodor; +4 Authors

doi: 10.1126/science.aat4096

pmid: 30166436

The opium poppy genome and morphinan production

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Abstract

Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks of addiction threaten many today. Guo et al. now deliver a draft of the opium poppy genome, which encompasses 2.72 gigabases assembled into 11 chromosomes and predicts more than 50,000 protein-coding genes. A particularly complex gene cluster contains many critical enzymes in the metabolic pathway that generates the alkaloid drugs noscapine and morphinan. Science , this issue p. 343

Country

United Kingdom

Related Organizations

Fudan University
China (People's Republic of)
Wellcome Sanger Institute
United Kingdom
White Rose Consortium: University of Leeds; University of Sheffield; University of York
United Kingdom
University of York
United Kingdom
First Affiliated Hospital of Xi'an Jiaotong University
China (People's Republic of)

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Keywords

1000, Benzylisoquinolines, Synteny, Evolution, Molecular, Morphinans, Gene Duplication, Multigene Family, Gene Order, Papaver, Gene Fusion, Genome, Plant, NADPH-Ferrihemoprotein Reductase, Plant Proteins

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