Hippocampal ripples down-regulate synapses
Copyright policy )Hippocampal ripples down-regulate synapses
Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression is dominant. Sharp wave and ripple events are transient high-frequency field oscillations that occur spontaneously during slow-wave sleep in the brain. Norimoto et al. found that these events induced long-term depression of hippocampal synapses and may thus help to refine recently acquired memories (see the Perspective by Draguhn). Science , this issue p. 1524 ; see also p. 1461
Long-Term Synaptic Depression, Down-Regulation, Hippocampus, Receptors, N-Methyl-D-Aspartate, Mice, Inbred C57BL, Mice, Memory, Synapses, Animals, Learning, Sleep
Long-Term Synaptic Depression, Down-Regulation, Hippocampus, Receptors, N-Methyl-D-Aspartate, Mice, Inbred C57BL, Mice, Memory, Synapses, Animals, Learning, Sleep
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