Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150
Copyright policy )Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150
Strong under pressure Human cytomegalovirus (HCMV) is a member of the herpesvirus family that can cause life-threatening infections in those who are immunocompromised. HCMV encodes a genome that is about 50% larger than that of herpes simplex virus 1 (the virus that causes cold sores), but these two viruses have similar-sized capsids. Yu et al. used cryo–electron microscopy to determine the structure of the HCMV capsid to 3.9-Å resolution. This is the first high-resolution capsid structure from the herpesvirus family. It reveals extensive interactions that stabilize the capsid to withstand the high pressure that comes from accommodating such a large genome. Science , this issue p. eaam6892
- University of California, San Francisco United States
- University of California, Los Angeles United States
Genome, General Science & Technology, Cryoelectron Microscopy, 610, Cytomegalovirus, Genome, Viral, Biological Sciences, Phosphoproteins, Viral Matrix Proteins, Infectious Diseases, Capsid, Sexually Transmitted Infections, 2.2 Factors relating to the physical environment, Humans, Capsid Proteins, Biochemistry and Cell Biology, Viral, Infection
Genome, General Science & Technology, Cryoelectron Microscopy, 610, Cytomegalovirus, Genome, Viral, Biological Sciences, Phosphoproteins, Viral Matrix Proteins, Infectious Diseases, Capsid, Sexually Transmitted Infections, 2.2 Factors relating to the physical environment, Humans, Capsid Proteins, Biochemistry and Cell Biology, Viral, Infection
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).105 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!