Exploring genetic suppression interactions on a global scale

descriptionPublicationkeyboard_double_arrow_right Article 04 Nov 2016 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 354 (issn: 0036-8075, eissn: 1095-9203,

Copyright policy )Funded by:CIHR | unidentified

Authors: Jolanda, van Leeuwen; Carles, Pons; Joseph C, Mellor; Takafumi N, Yamaguchi; Helena, Friesen; John, Koschwanez; Mojca Mattiazzi, Ušaj; +35 Authors

doi: 10.1126/science.aag0839

pmid: 27811238

pmc: PMC5562937

Exploring genetic suppression interactions on a global scale

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Abstract

A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set reveals a set of general properties that can be used to predict suppression interactions. Furthermore, the study provides a template for extending suppression studies to other genes or to more complex organisms. Science , this issue p. 599

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Keywords

Saccharomyces cerevisiae Proteins, Suppression, Genetic, Genes, Fungal, Chromosome Mapping, Gene Regulatory Networks, Saccharomyces cerevisiae, Genes, Suppressor, Cell Physiological Phenomena

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