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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Authors: Bryant, JM; Grogono, DM; Rodriguez-Rincon, D; Everall, I; Brown, KP; Moreno, P; Verma, D; +74 Authors

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Abstract

Global spread of aggressive mycobacteria Many mycobacteria, in addition to those causing leprosy and tuberculosis, are capable of infecting humans. Some can be particularly dangerous in patients suffering from immunosuppression or chronic disease, such as cystic fibrosis (CF). Bryant et al. observed clusters of near-identical isolates of drug-resistant Mycobacterium abscessus in patients reporting to CF clinics. The similarity of the isolates suggests transmission between patients, rather than environmental acquisition. Although this bacterium is renowned for its environmental resilience, the mechanism for its long-distance transmission among the global CF patient community remains a puzzle. Science , this issue p. 751

Countries
United Kingdom, Australia, Netherlands, Australia
Keywords

Cystic Fibrosis, aerosol, PULMONARY INFECTION, Drug Resistance, Mice, SCID, Communicable Diseases, Emerging, DISEASE, Mice, cough, Drug Resistance, Multiple, Bacterial, EPIDEMIOLOGY, bacteria, Lung, Phylogeny, Emerging, Genome, Incidence, Bacterial, Nontuberculous Mycobacteria, Single Nucleotide, Genomics, PREVALENCE, Multidisciplinary Sciences, droplet nuclei, 2700 Medicine, MASSILIENSE, Science & Technology - Other Topics, NTM, Multiple, Sequence Analysis, General Science & Technology, ABSCESSUS, 610, Mycobacterium Infections, Nontuberculous, SCID, Communicable Diseases, Polymorphism, Single Nucleotide, ENVIRONMENTAL SOURCES, CYSTIC-FIBROSIS CENTER, MD Multidisciplinary, 616, Pneumonia, Bacterial, Animals, Humans, Polymorphism, Mycobacterium Infections, Science & Technology, Nontuberculous, LUNG-TRANSPLANT, PSEUDOMONAS-AERUGINOSA, Pneumonia, DNA, Sequence Analysis, DNA, bioaerosols, 1000 General, Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences, Genome, Bacterial

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    541
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 0.1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
541
Top 0.1%
Top 1%
Top 0.1%
Green
bronze