Long-read sequence assembly of the gorilla genome
Copyright policy )Long-read sequence assembly of the gorilla genome
Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al. used long-read sequencing technology to improve genome data on our close relative the gorilla. Sequencing from a single individual decreased assembly fragmentation and recovered previously missed genes and noncoding loci. Mapping short-read sequences from additional gorillas helped reconstruct a “pan” gorilla sequence documenting genetic variation. Comparison with human genomes revealed species-specific differences ranging in size from one to thousands of bases in length, including some that are likely to affect gene regulation. Science , this issue p. 10.1126/science.aae0344
- Howard Hughes Medical Institute United States
- Pacific Biosciences United States
- University of California, San Francisco United States
- University of California, Santa Cruz United States
- Washington University in St. Louis United States
570, Evolution, General Science & Technology, 1.1 Normal biological development and functioning, Bioinformatics and Computational Biology, Evolution, Molecular, Contig Mapping, 616, Genetics, Animals, Humans, Expressed Sequence Tags, Genome, Gorilla gorilla, Genome, Human, Human Genome, Molecular, Genetic Variation, DNA, Genomics, Sequence Analysis, DNA, Biological Sciences, Female, Generic health relevance, Sequence Analysis, Sequence Alignment, Biotechnology, Human
570, Evolution, General Science & Technology, 1.1 Normal biological development and functioning, Bioinformatics and Computational Biology, Evolution, Molecular, Contig Mapping, 616, Genetics, Animals, Humans, Expressed Sequence Tags, Genome, Gorilla gorilla, Genome, Human, Human Genome, Molecular, Genetic Variation, DNA, Genomics, Sequence Analysis, DNA, Biological Sciences, Female, Generic health relevance, Sequence Analysis, Sequence Alignment, Biotechnology, Human
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