Nongenetic functions of the genome
Copyright policy )Nongenetic functions of the genome
The nongenetic roles of the nucleus The eukaryotic cell nucleus provides a home for the genetic material and accessory proteins. As a physical entity, the nucleus also plays an important role in cell dynamics. Bustin and Misteli Review the impacts that the nucleus can have as a nongenetic force. For example, compacted DNA and the nuclear membrane affect nuclear morphology, the cellular response to mechanical force, cell migration, and cell signaling. Chromatin is not only affected by physical forces in cells but participates in a crosstalk of signaling inside cells. Science , this issue p. 10.1126/science.aad6933
- National Cancer Institute United States
Cell Nucleus, Genome, Cell Movement, Animals, Humans, Nucleic Acid Conformation, DNA, Stress, Mechanical, Mechanotransduction, Cellular, DNA Damage, Signal Transduction
Cell Nucleus, Genome, Cell Movement, Animals, Humans, Nucleic Acid Conformation, DNA, Stress, Mechanical, Mechanotransduction, Cellular, DNA Damage, Signal Transduction
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