Molecular architecture of the human U4/U6.U5 tri-snRNP
Copyright policy )Molecular architecture of the human U4/U6.U5 tri-snRNP
A human spliceosomal subcomplex The spliceosome is an RNA and protein molecular machine that cuts out introns from messenger RNAs. Agafonov et al. used cryo-electron microscopy to determine the structure of the largest intermediate subcomplex on the assembly pathway for the human spliceosome (see the Perspective by Cate). The structure shows substantial differences from the equivalent yeast complex. It also reveals how the subcomplex must dock onto the rest of the spliceosome and hints at the structural changes the complex must go through to form the mature spliceosome. Science , this issue p. 1416 ; see also p. 1390
- University of Göttingen Germany
- Max Planck Society Germany
- Universitätsmedizin Göttingen Germany
- Max Planck Institute for Multidisciplinary Sciences Germany
Models, Molecular, Saccharomyces cerevisiae Proteins, Protein Conformation, Ribonucleoprotein, U4-U6 Small Nuclear, Cryoelectron Microscopy, RNA-Binding Proteins, Crystallography, X-Ray, Peptide Elongation Factors, Ribonucleoproteins, Small Nuclear, DEAD-box RNA Helicases, Enzyme Activation, Schizosaccharomyces, Humans, Ubiquitin Thiolesterase, RNA Helicases, Ribonucleoprotein, U5 Small Nuclear, HeLa Cells
Models, Molecular, Saccharomyces cerevisiae Proteins, Protein Conformation, Ribonucleoprotein, U4-U6 Small Nuclear, Cryoelectron Microscopy, RNA-Binding Proteins, Crystallography, X-Ray, Peptide Elongation Factors, Ribonucleoproteins, Small Nuclear, DEAD-box RNA Helicases, Enzyme Activation, Schizosaccharomyces, Humans, Ubiquitin Thiolesterase, RNA Helicases, Ribonucleoprotein, U5 Small Nuclear, HeLa Cells
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