The reproducibility problem in science is a familiar issue, not only within the scientific community, but with the general public as well. Recent developments in social psychology (such as fraudulent research by D. Stapel) and cell biology (the Amgen Inc. and Bayer AG reports on how rarely they could reproduce published results) have become widely known. Nearly every field is affected, from clinical trials and neuroimaging, to economics and computer science. Obvious solutions include more research on statistical and behavioral fixes for irreproducibility, activism for policy changes, and demanding more pre-registration and data sharing from grantees. Two Perspectives in this issue (pp. 1420 and 1422) describe how journals and academic institutions can foster a culture of reproducibility. Transparency is central to improving reproducibility, but it is expensive and time-consuming. What can be done to alleviate those obstacles?