Cancer and the microbiota

descriptionPublicationkeyboard_double_arrow_right Article 03 Apr 2015 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 348, pages 80-86 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Wendy S, Garrett;

doi: 10.1126/science.aaa4972

pmid: 25838377

pmc: PMC5535753

Cancer and the microbiota

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Abstract

A host’s microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.

Related Organizations

Dana-Farber Cancer Institute
United States
Harvard University
United States
Massachusetts Institute of Technology
United States

Keywords

Carcinogenesis, Microbiota, Neoplasms, Humans, Immunotherapy

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