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Science
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Science
Article . 2015 . Peer-reviewed
License: http://www.sciencemag.org/about/science-licenses-journal-article-reuse
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Science
Article . 2015
Data sources: Europe PubMed Central
https://dx.doi.org/10.1126/sci...
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The structure of the dynactin complex and its interaction with dynein

descriptionPublicationkeyboard_double_arrow_right Article 27 Mar 2015 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 347, pages 1,441-1,446 (issn: 0036-8075, eissn: 1095-9203, Copyright policy )Funded by:UKRI | The structure and mechani..., WT | Transport of cargo by cyt..., WT | unidentified
Authors: Linas, Urnavicius; Kai, Zhang; Aristides G, Diamant; Carina, Motz; Max A, Schlager; Minmin, Yu; Nisha A, Patel; +2 Authors

doi: 10.1126/science.aaa4080

pmid: 25814576

pmc: PMC4413427

The structure of the dynactin complex and its interaction with dynein

Abstract

Making a molecular motor fit for purpose Dynactin is an essential cofactor of the microtubule motor, cytoplasmic dynein. Dynactin contains 23 subunits built around a short filament of an actin-related protein (Arp1). How dynactin is assembled, how it functions with dynein, and why it is built around an actin-like filament is unclear. Urnavicius et al. combined cryo–electron microscopy structural studies and a crystal structure to determine the three-dimensional architecture of dynactin and how it interacts with dynein. Science , this issue p. 1441

Related Organizations
Keywords

Swine, Cryoelectron Microscopy, Dyneins, Dynactin Complex, Actins, Protein Structure, Secondary, Protein Structure, Tertiary, Mice, Protein Subunits, Multiprotein Complexes, Protein Interaction Mapping, Animals, Humans, Microtubule-Associated Proteins

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 398
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 0.1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
398
Top 0.1%
Top 1%
Top 0.1%
bronze
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