Sperm Autoantibodies in Vasectomized Rats of Different Inbred Strains

descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 1977 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 197, pages 1,282-1,283 (issn: 0036-8075, eissn: 1095-9203,

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Authors: P E, Bigazzi; L L, Kosuda; L L, Harnick;

doi: 10.1126/science.897668

pmid: 897668

Sperm Autoantibodies in Vasectomized Rats of Different Inbred Strains

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Abstract

An immune response to antigens of spermatozoa occurs after vasectomy in rats of some inbred strains, but not in others. Antibodies to rat spermatozoa were detected by indirect immunofluorescence in some of the serums of vasectomized rats of the following strains: 80 percent of Lewis, 47 percent of Brown Norway, 13 percent of Buffalo, 12 percent of Wistar-Furth, and 11 percent of ACI rats. No such antibodies were detected in the serums of vasectomized Fischer, Dark Agouti, and Sprague-Dawley rats.

Keywords

Male, Time Factors, Genetic Linkage, Rats, Inbred Strains, Spermatozoa, Rats, Species Specificity, Histocompatibility Antigens, Vasectomy, Animals, Acrosome, Autoantibodies

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