Somatostatin: Analogs with Selected Biological Activities
Copyright policy )Somatostatin: Analogs with Selected Biological Activities
[D-Cys 14 ]-Somatostatin is the first analog of somatostatin found to be more potent in inhibiting glucagon and growth hormone secretion than it is in inhibiting insulin secretion. [D-Trp 8 ]-Somatostatin is eight to ten times more potent than somatostatin in inhibiting insulin, glucagon, and growth hormone secretion. [D-Trp 8 ,D-Cys 14 ]-Somatostatin is more potent than [D-Cys 14 ]-somatostatin, but retains its relative selectivity in being a more potent inhibitor of the secretion of glucagon and growth hormone than of insulin.
- Salk Institute for Biological Studies United States
Blood Glucose, Male, Portal Vein, In Vitro Techniques, Glucagon, Rats, Structure-Activity Relationship, Pituitary Gland, Anterior, Growth Hormone, Insulin Secretion, Animals, Insulin, Biological Assay, Somatostatin
Blood Glucose, Male, Portal Vein, In Vitro Techniques, Glucagon, Rats, Structure-Activity Relationship, Pituitary Gland, Anterior, Growth Hormone, Insulin Secretion, Animals, Insulin, Biological Assay, Somatostatin
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