Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4
Copyright policy )Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4
The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the γ chain cross-linked with IL-2, also immunoprecipitated the γ chain when cross-linked with IL-4. These results suggest that the IL-2 receptor γ chain is functionally involved in the IL-4 receptor complex.
- Tohoku University Japan
- University of Tokyo Japan
T-Lymphocytes, Antibodies, Monoclonal, Receptors, Interleukin-2, Cell Line, Rats, Receptors, Interleukin-4, Mice, Receptors, Mitogen, Animals, Interleukin-2, Interleukin-4, Rats, Wistar, Cell Division, Signal Transduction
T-Lymphocytes, Antibodies, Monoclonal, Receptors, Interleukin-2, Cell Line, Rats, Receptors, Interleukin-4, Mice, Receptors, Mitogen, Animals, Interleukin-2, Interleukin-4, Rats, Wistar, Cell Division, Signal Transduction
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