In Vivo Activation of Zoxazolamine Metabolism by Flavone

descriptionPublicationkeyboard_double_arrow_right Article 25 Jun 1982 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 216, pages 1,419-1,421 (issn: 0036-8075, eissn: 1095-9203,

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Authors: J M, Lasker; , Huang M-T; A H, Conney;

doi: 10.1126/science.7089530

pmid: 7089530

In Vivo Activation of Zoxazolamine Metabolism by Flavone

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Abstract

The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate severalfold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a xenobiotic that is an activator of hepatic microsomal monooxygenases in vitro.

Related Organizations

Roche (Switzerland)
Switzerland

Keywords

Flavonoids, Zoxazolamine, Hydroxylation, Rats, Drug Combinations, Kinetics, Animals, Newborn, Cytochrome P-450 Enzyme System, Microsomes, Liver, Animals, Drug Interactions

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