Hemin Lyses Malaria Parasites

descriptionPublicationkeyboard_double_arrow_right Article 06 Nov 1981 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 214, pages 667-669 (issn: 0036-8075, eissn: 1095-9203,

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Authors: A U, Orjih; H S, Banyal; R, Chevli; C D, Fitch;

doi: 10.1126/science.7027441

pmid: 7027441

Hemin Lyses Malaria Parasites

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Abstract

Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.

Related Organizations

Saint Louis University
United States
Saint Louis University
Spain

Keywords

Mice, Plasmodium berghei, Drug Resistance, Animals, Hemin, Chloroquine, Drug Interactions, Heme

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