Are Ions Involved in the Gating of Calcium Channels?

descriptionPublicationkeyboard_double_arrow_right Article 08 Oct 1982 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 218, pages 153-156 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Y, Saimi; C, Kung;

doi: 10.1126/science.6289432

pmid: 6289432

Are Ions Involved in the Gating of Calcium Channels?

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Abstract

The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.

Related Organizations

University of Wisconsin–Oshkosh
United States
University of Wisconsin–Madison
United States

Keywords

Kinetics, Paramecium, Barium, Strontium, Cell Membrane, Animals, Calcium, Ion Channels, Membrane Potentials

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