
pmid: 6283633
Intermediate lobes isolated from rat pituitary glands incorporated [ 35 S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.
Radioisotope Dilution Technique, Pro-Opiomelanocortin, In Vitro Techniques, Sulfuric Acids, Sulfur Radioisotopes, Tritium, Rats, Kinetics, Adrenocorticotropic Hormone, Leucine, Pituitary Hormones, Anterior, Pituitary Gland, Animals, Amino Acid Sequence, Protein Precursors
Radioisotope Dilution Technique, Pro-Opiomelanocortin, In Vitro Techniques, Sulfuric Acids, Sulfur Radioisotopes, Tritium, Rats, Kinetics, Adrenocorticotropic Hormone, Leucine, Pituitary Hormones, Anterior, Pituitary Gland, Animals, Amino Acid Sequence, Protein Precursors
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