J Genes for Heavy Chain Immunoglobulins of Mouse

descriptionPublicationkeyboard_double_arrow_right Article 05 Sep 1980 United States English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 209, pages 1,128-1,132 (issn: 0036-8075, eissn: 1095-9203,

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Authors: Newell, N; Richards, J E; Tucker, P W; Blattner, F R;

doi: 10.1126/science.6250219

pmid: 6250219

J Genes for Heavy Chain Immunoglobulins of Mouse

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Abstract

A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4Aλ phage vector system, was shown to contain the μ heavy chain constant region (C H μ) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of heavy chain variable regions. These genes are located in genomic DNA about eight kilobase pairs to the 5 ′ side of the C H μ gene. The complete nucleotide sequence of a 1120-base pair stretch of DNA that includes the two J genes has been determined.

Country

United States

Related Organizations

University of Wisconsin–Madison
United States
University of Wisconsin–Oshkosh
United States
Jackson Laboratory
United States

Keywords

Base Sequence, Genetic Linkage, Immunoglobulin mu-Chains, Physiology:, DNA, Recombinant, Immunoglobulin Variable Region, DNA Restriction Enzymes, Mice, Strains:, Genes, Morphology:, Animals, Binding Sites, Antibody, Hereditary Factors:, Immunoglobulin Heavy Chains, Serology:

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