Antibody to Hepatitis B Virus Induced by Injecting Antibodies to the Idiotype

descriptionPublicationkeyboard_double_arrow_right Article 02 Mar 1984 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 223, pages 930-931 (issn: 0036-8075, eissn: 1095-9203,

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Authors: R C, Kennedy; J L, Melnick; G R, Dreesman;

doi: 10.1126/science.6198721

pmid: 6198721

Antibody to Hepatitis B Virus Induced by Injecting Antibodies to the Idiotype

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Abstract

Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.

Related Organizations

Baylor College of Medicine
United States

Keywords

Epitopes, Mice, Mice, Inbred BALB C, Hepatitis B Surface Antigens, Immunoglobulin Idiotypes, Species Specificity, Immunization, Passive, Animals, Cross Reactions, Hepatitis B Antibodies

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