Biotin Enhances Guanylate Cyclase Activity

descriptionPublicationkeyboard_double_arrow_right Article 18 Jun 1982 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 216, pages 1,329-1,330 (issn: 0036-8075, eissn: 1095-9203,

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Authors: D L, Vesely;

doi: 10.1126/science.6123152

pmid: 6123152

Biotin Enhances Guanylate Cyclase Activity

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Abstract

Biotin and its analog, (+)-biotin- p -nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.

Related Organizations

University of Arkansas for Medical Sciences
United States

Keywords

Colon, Myocardium, Biotin, Rats, Inbred Strains, Kidney, Rats, Kinetics, Liver, Guanylate Cyclase, Cerebellum, Animals

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