Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor
Copyright policy )Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor
Complementary DNA clones of genes induced by platelet-derived growth factor (PDGF) in BALB/c-3T3 cells were isolated; one such clone contains a domain having nucleotide sequence homology with the third exon of c- fos . This nucleotide sequence homology is reflected in the predicted amino acid sequences of the gene products. Under low stringency conditions, the mouse v- fos gene cross-hybridizes with the PDGF-inducible complementary DNA clone. However, the messenger RNA transcripts of mouse c- fos and the new fos -related gene can be distinguished by gel electrophoresis and by S1 nuclease analysis. Expression of the authentic c- fos gene is induced by PDGF and superinduced by the combination of PDGF and cycloheximide.
- Dana-Farber Cancer Institute United States
- Salk Institute for Biological Studies United States
- Harvard University United States
Platelet-Derived Growth Factor, Mice, Inbred BALB C, Base Sequence, Transcription, Genetic, Single-Strand Specific DNA and RNA Endonucleases, Nucleic Acid Hybridization, DNA, DNA Restriction Enzymes, Oncogenes, Endonucleases, Mice, Genes, DNA Transposable Elements, Animals, Amino Acid Sequence, Cloning, Molecular, Cells, Cultured
Platelet-Derived Growth Factor, Mice, Inbred BALB C, Base Sequence, Transcription, Genetic, Single-Strand Specific DNA and RNA Endonucleases, Nucleic Acid Hybridization, DNA, DNA Restriction Enzymes, Oncogenes, Endonucleases, Mice, Genes, DNA Transposable Elements, Animals, Amino Acid Sequence, Cloning, Molecular, Cells, Cultured
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