Periodicity of Deoxyribonuclease I Digestion of Chromatin

descriptionPublicationkeyboard_double_arrow_right Article 25 May 1979 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 204, pages 855-858 (issn: 0036-8075, eissn: 1095-9203,

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Authors: A, Prunell; R D, Kornberg; L, Lutter; A, Klug; M, Levitt; F H, Crick;

doi: 10.1126/science.441739

pmid: 441739

Periodicity of Deoxyribonuclease I Digestion of Chromatin

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Abstract

Two methods have been used to measure the single-strand lengths of the DNA fragments produced by deoxyribonuclease I digestion of chromatin. The average lengths obtained are multiples of about 10.4 bases, significantly different from the value of 10 previously reported. This periodicity in fragment lengths is closely related to the periodicity of the DNA double helix in chromatin, but the two values need not be exactly the same.

Related Organizations

Stanford University
United States
Medical Research Council
United Kingdom
Salk Institute for Biological Studies
United States
MRC Laboratory of Molecular Biology
United Kingdom

Keywords

Molecular Weight, Deoxyribonucleases, Base Sequence, Hydrolysis, Animals, Chromatin, Rats

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