Acceleration of Plasma Bicarbonate Conversion to Carbon Dioxide by Pulmonary Carbonic Anhydrase

descriptionPublicationkeyboard_double_arrow_right Article 27 Jan 1978 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 199, pages 427-429 (issn: 0036-8075, eissn: 1095-9203,

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Authors: R M, Effros; R S, Chang; P, Silverman;

doi: 10.1126/science.413195

pmid: 413195

Acceleration of Plasma Bicarbonate Conversion to Carbon Dioxide by Pulmonary Carbonic Anhydrase

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Abstract

In isolated rabbit lungs perfused with solutions containing little or no carbonic anhydrase activity, nearly complete equilibration between H 14 CO 3 - and 14 CO 2 occurs during a single circulation. This equilibration can be inhibited by blocking pulmonary carbonic anhydrase with acetazolamide.

Related Organizations

University of California, Los Angeles
United States

Keywords

Acetazolamide, Perfusion, Bicarbonates, Animals, Rabbits, Carbon Dioxide, Lung, Carbonic Anhydrases

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