Evolution in Inbred Strains of Mice Appears Rapid

descriptionPublicationkeyboard_double_arrow_right Article 07 Jun 1985 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 228, pages 1,169-1,175 (issn: 0036-8075, eissn: 1095-9203,

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Authors: W M, Fitch; W R, Atchley;

doi: 10.1126/science.4001935

pmid: 4001935

Evolution in Inbred Strains of Mice Appears Rapid

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Abstract

Genetic variation at 97 loci in ten commonly used inbred strains of mice is greatly in excess of that expected under current assumptions. Evidence against all of the readily apparent explanations is presented and the possibility of early selection for heterozygosity or of conversion is suggested. The common ancestor of these strains is estimated to have occurred about 150 years ago.

Related Organizations

University of Wisconsin–Madison
United States
University of Wisconsin–Oshkosh
United States

Keywords

Heterozygote, Mice, Time Factors, Species Specificity, Mutation, Animals, Mice, Inbred Strains, Biological Evolution

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