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Throttles and Dampers: Controlling the Engine of Membrane Fusion

descriptionPublicationkeyboard_double_arrow_right Article 23 May 1997Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 276, pages 1,212-1,212 (issn: 0036-8075, eissn: 1095-9203,

Authors: Thomas H. Söllner; James E. Rothman;

doi: 10.1126/science.276.5316.1212

pmid: 9182331

Throttles and Dampers: Controlling the Engine of Membrane Fusion

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Abstract

Thomas H. SA¶llner Vesicles deliver cargo to targets in all parts of the cell. New findings in this issue show that two regulatory proteins, Ypt1p (a Rab-family member) and Sly1p (a Sec1-family member), bind to a SNARE protein located on the target. Rothman and SA¶llner, in their Perspective, outline how these two proteins are likely to act as a throttle and brake for the process of membrane fusion that distributes the cellular constituents to their final destinations. See the report by Lupashin and Waters in this issue on p. 1255.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

Keywords

Saccharomyces cerevisiae Proteins, Time Factors, Vesicular Transport Proteins, Membrane Proteins, Biological Transport, Membrane Fusion, GTP Phosphohydrolases, GTP-Binding Proteins, rab GTP-Binding Proteins, Guanosine Triphosphate, Caenorhabditis elegans Proteins, SNARE Proteins, Molecular Chaperones

5 Research products, page 1 of 1

GTP-binding protein YPT1
2017IsRelatedTo
Ras-related protein SEC4
2017IsRelatedTo
Protein transport protein SEC1
2017IsRelatedTo
Integral membrane protein SED5
2017IsRelatedTo
Protein SLY1
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	111
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%