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The Whole Lactose Repressor

Name: The Whole Lactose Repressor
Creator: Kathleen S. Matthews
Keywords: DNA, Bacterial, Isopropyl Thiogalactoside, 0301 basic medicine, Protein Folding, 0303 health sciences, Binding Sites, Operator Regions, Genetic, Protein Conformation, Escherichia coli Proteins, Crystallography, X-Ray

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1996 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 271, pages 1,245-1,246 (issn: 0036-8075, eissn: 1095-9203,

Authors: Kathleen S. Matthews;

doi: 10.1126/science.271.5253.1245

pmid: 8638104

The Whole Lactose Repressor

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Abstract

The lactose repressor turns the bacterial genes for lactose metabolism on and off. This system has served as a blueprint for the study of both eukaryotic and prokaryotic gene regulation for decades. In this issue of Science , the crystal structure of the whole lactose repressor in a complex with DNA and its inducer is reported. In her Perspective, K. Matthews discusses the significance of this landmark event.

Related Organizations

Rice University
United States

Keywords

DNA, Bacterial, Isopropyl Thiogalactoside, Protein Folding, Binding Sites, Operator Regions, Genetic, Protein Conformation, Escherichia coli Proteins, Crystallography, X-Ray, Ligands, Repressor Proteins, Allosteric Regulation, Bacterial Proteins, Lac Operon, Mutagenesis, Lac Repressors

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	40
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average