Prenylated Proteins: the Structure of the Isoprenoid Group

descriptionPublicationkeyboard_double_arrow_right Article 19 Jan 1990 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 247, pages 318-320 (issn: 0036-8075, eissn: 1095-9203,

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Authors: H C, Rilling; E, Breunger; W W, Epstein; P F, Crain;

doi: 10.1126/science.2296720

pmid: 2296720

Prenylated Proteins: the Structure of the Isoprenoid Group

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Abstract

The mevalonate-derived portion of a prenylated protein from Chinese hamster ovary cells has been established as diterpenoid (C 20 ). This group is linked to a carboxyl-terminal cysteine as a thioether. It was removed from the protein by hydrazinolysis followed by Raney nickel desulfurization, and the resulting hydrocarbon fraction was analyzed by gas chromatography-mass spectrometry.

Related Organizations

University of Utah
United States

Keywords

Molecular Structure, Ovary, Mevalonic Acid, Proteins, Gas Chromatography-Mass Spectrometry, Cell Line, Cricetinae, Animals, Female, Diterpenes, Protein Precursors, Protein Processing, Post-Translational

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