A Family of AMPA-Selective Glutamate Receptors
Copyright policy )A Family of AMPA-Selective Glutamate Receptors
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate > glutamate > kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).
- Heidelberg University Germany
- Max Planck Institute for Medical Research Germany
- Max Planck Society Germany
Oxadiazoles, Kainic Acid, Base Sequence, Molecular Sequence Data, Brain, Quisqualic Acid, Rats, Receptors, Neurotransmitter, Kinetics, Glutamates, Receptors, Glutamate, Organ Specificity, Multigene Family, Sequence Homology, Nucleic Acid, Animals, Amino Acid Sequence, RNA, Messenger, Oligonucleotide Probes, Ibotenic Acid, Oxazoles
Oxadiazoles, Kainic Acid, Base Sequence, Molecular Sequence Data, Brain, Quisqualic Acid, Rats, Receptors, Neurotransmitter, Kinetics, Glutamates, Receptors, Glutamate, Organ Specificity, Multigene Family, Sequence Homology, Nucleic Acid, Animals, Amino Acid Sequence, RNA, Messenger, Oligonucleotide Probes, Ibotenic Acid, Oxazoles
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