Platelet Factor 4: An Inhibitor of Collagenase

descriptionPublicationkeyboard_double_arrow_right Article 03 Mar 1978 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 199, pages 991-992 (issn: 0036-8075, eissn: 1095-9203,

Copyright policy )

Authors: J, Hiti-Harper; H, Wohl; E, Harper;

doi: 10.1126/science.203038

pmid: 203038

Platelet Factor 4: An Inhibitor of Collagenase

- Summary
- Subjects
- Metrics

Abstract

Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4 inhibits collagenase, in addition to neutralizing heparin.

Related Organizations

University of California, San Diego
United States
University of California, San Diego
United States

Keywords

Heparin, Glycine, Platelet Factor 4, Blood Coagulation Factors, Microbial Collagenase, Organ Culture Techniques, Humans, Collagen, Granulocytes, Skin

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	124
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%