Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

descriptionPublicationkeyboard_double_arrow_right Article 04 Oct 1974 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 186, pages 63-65 (issn: 0036-8075, eissn: 1095-9203,

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Authors: D H, Ross; M A, Medina; H L, Cardenas;

doi: 10.1126/science.186.4158.63

pmid: 4420821

Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

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Abstract

Administration of morphine or ethanol to rats produces a decrease in regional brain calcium in vivo. This effect is selectively antagonized by the stereospecific narcotic antagonist naloxone. Reserpine and the dopamine-acetaldehyde conjugate salsolinol also produce a depletion of regional brain calcium, but only the salsolinol depletion is antagonized by naloxone. Experiments with naloxone provide evidence for two calcium-sensitive pools in the central nervous system.

Related Organizations

The University of Texas Health Science Center at Houston
United States
The University of Texas Health Science Center at San Antonio
United States

Keywords

Brain Chemistry, Cerebral Cortex, Male, Reserpine, Ethanol, Morphine, Naloxone, Dopamine, Spectrophotometry, Atomic, Hypothalamus, Brain, Acetaldehyde, Hippocampus, Corpus Striatum, Rats, Depression, Chemical, Animals, Calcium, Drug Antagonism

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