Neurochemical Correlate of a Spatial Preference in Rats

descriptionPublicationkeyboard_double_arrow_right Article 16 Aug 1974 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 185, pages 623-625 (issn: 0036-8075, eissn: 1095-9203,

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Authors: B, Zimmerberg; S D, Glick; T P, Jerussi;

doi: 10.1126/science.185.4151.623

pmid: 4858234

Neurochemical Correlate of a Spatial Preference in Rats

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Abstract

Spatial (left or right) preferences were determined for rats given foot shock in a T-maze. The animals were killed, and left and right striata were assayed separately for dopamine and left and right teldiencephalic regions were assayed for norepinephrine. Dopamine content was significantly higher (by 12 percent) in the striata contralateral to rats' side preferences than in the ipsilateral striata; there was no such difference for teldiencephalic norepinephrine. The small asymmetry in striatal dopamine content is not due to any learning- or stress-related change induced by the testing procedure but is probably inherent in normal rats. Some spatial behavior appears to be the manifestation of a normal and specific difference in the activity of left and right nigrostriatal systems.

Related Organizations

Newark Beth Israel Medical Center
United States
Icahn School of Medicine at Mount Sinai
United States
Beth Israel Deaconess Medical Center
United States

Keywords

Brain Chemistry, Electroshock, Dextroamphetamine, Behavior, Animal, Dopamine, Spatial Behavior, Motor Activity, Corpus Striatum, Rats, Substantia Nigra, Norepinephrine, Neural Pathways, Animals, Humans, Stereotyped Behavior, Dominance, Cerebral

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