Ethanol-Induced Depletion of Cerebellar Guanosine 3′,5′-Cyclic Monophosphate

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 1976 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 193, pages 58-59 (issn: 0036-8075, eissn: 1095-9203,

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Authors: J D, Redos; G N, Catravas; W A, Hunt;

doi: 10.1126/science.180596

pmid: 180596

Ethanol-Induced Depletion of Cerebellar Guanosine 3′,5′-Cyclic Monophosphate

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Abstract

Single doses of ethanol induce a severe depletion (95 percent) of cerebellar guanosine 3′,5′-cyclic monophosphate (cyclic GMP) within 1 hour after administration. The degree of this depletion is dose-dependent and is a function of the amount of ethanol in the blood. Interactions between ethanol and cyclic GMP may account for some of the intoxicating properties of ethanol.

Related Organizations

American University
United States
Armed Forces Radiobiology Research Institute
United States

Keywords

Male, Time Factors, Ethanol, Cerebellum, Animals, Cyclic GMP, Rats

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