Immunoglobulin M: Fixation of Human Complement by the Fc Fragment
Copyright policy )Immunoglobulin M: Fixation of Human Complement by the Fc Fragment
The Fc fragment [(Fc) 5 μ, with a molecular weight of 342,000] of human immunoglobulin M from patients with Waldenström's macroglobulinemia has a complement fixing ability approximately 19 times greater on a molar basis than that of the parent immunoglobulin M. This fragment, which occurs naturally as a pentamer fixes human but not guinea pig complement, and this activity remains unchanged even after the fragment is reduced to the monomeric form.
- State University of New York at Potsdam United States
- University at Buffalo, State University of New York United States
Binding Sites, Complement Fixation Tests, Guinea Pigs, Immunoglobulins, Chromatography, Ion Exchange, Molecular Weight, Immunoglobulin M, Immunoglobulin G, Animals, Humans, Waldenstrom Macroglobulinemia
Binding Sites, Complement Fixation Tests, Guinea Pigs, Immunoglobulins, Chromatography, Ion Exchange, Molecular Weight, Immunoglobulin M, Immunoglobulin G, Animals, Humans, Waldenstrom Macroglobulinemia
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