Isozymes of Phenylalanine Hydroxylase

descriptionPublicationkeyboard_double_arrow_right Article 25 Feb 1972 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 175, pages 903-905 (issn: 0036-8075, eissn: 1095-9203,

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Authors: J A, Barranger; P J, Geiger; A, Huzino; S P, Bessman;

doi: 10.1126/science.175.4024.903

pmid: 4257648

Isozymes of Phenylalanine Hydroxylase

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Abstract

Three isozymes of phenylalanine hydroxylase exist in adult rat liver. They are chromatographically unique. Partial characterization suggests that they are similar in chemical properties and differ only in charge. Estimation of the Stokes radii indicates that the isozymes have similar molecular weights of about 200,000. Two isozymes exist in human fetal liver. Alterations of the relative amounts of these isozymes may control the phenotype of the disease phenylketonuria.

Related Organizations

University of California System
United States
University of Southern California
United States

Keywords

Chromatography, Hot Temperature, Fenclonine, Phenylalanine Hydroxylase, Hydrogen-Ion Concentration, Mixed Function Oxygenases, Rats, Isoenzymes, Molecular Weight, Kinetics, Fetus, Liver, Chromatography, Gel, Animals, Humans, Tyrosine

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