Oligodeoxyribonucleotides: Chemical Synthesis in Anhydrous Base

descriptionPublicationkeyboard_double_arrow_right Article 27 Feb 1970 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 167, pages 1,266-1,268 (issn: 0036-8075, eissn: 1095-9203,

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Authors: R, Von Tigerstrom; M, Smith;

doi: 10.1126/science.167.3922.1266

pmid: 5411914

Oligodeoxyribonucleotides: Chemical Synthesis in Anhydrous Base

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Abstract

The sugar hydroxyl of a methoxytrityldeoxyribonucleoside reacts with a methoxytrityldeoxyribonucleoside phosphorofluoridate in dimethylformamide and potassium tertiary butoxide to yield the protected dinucleoside monophosphate. The reaction is fast and specific, and is used in a stepwise synthesis to prepare trinucleoside diphosphate and tetranucleoside triphosphate.

Related Organizations

University of British Columbia
Canada

Keywords

Nucleotides, Dimethylformamide, Nucleosides, Oxides, Chromatography, Ion Exchange

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