Magnesium Pemoline: Enhancement of Brain RNA Polymerases

descriptionPublicationkeyboard_double_arrow_right Article 11 Feb 1966 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 151, pages 702-703 (issn: 0036-8075, eissn: 1095-9203,

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Authors: A J, Glasky; L N, Simon;

doi: 10.1126/science.151.3711.702

pmid: 4379533

Magnesium Pemoline: Enhancement of Brain RNA Polymerases

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Abstract

The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.

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Abbott (United States)
United States

Keywords

Imipramine, Pemoline, Brain, In Vitro Techniques, Nucleotidyltransferases, Methamphetamine, Rats, Pargyline, Piperidines, Methylphenidate, Animals, RNA, Anticonvulsants, Magnesium, Oxazoles, Trimethadione

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