Insulin: Inducer of Pyruvate Kinase

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 1965 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 149, pages 65-67 (issn: 0036-8075, eissn: 1095-9203,

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Authors: G, WEBER; N B, STAMM; E A, FISHER;

doi: 10.1126/science.149.3679.65

pmid: 14300524

Insulin: Inducer of Pyruvate Kinase

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Abstract

The hepatic pyruvate kinase activity markedly decreased when rats were made diabetic by alloxan injection. Insulin treatment induced new synthesis of pyruvate kinase which was prevented by injection of ethionine and actinomycin D. The evidence indicated that the increased pyruvate kinase activity induced by insulin entails at a certain stage a stimulation of the synthesis of certain RNA species relevant to the production of this enzyme.

Related Organizations

Indiana University
United States
Indiana University School of Medicine
United States

Keywords

Pharmacology, Research, Pyruvate Kinase, Proteins, Toxicology, Diabetes Mellitus, Experimental, Rats, Liver, Transferases, Dactinomycin, Animals, Insulin, RNA, Ethionine

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