Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus
Copyright policy )Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus
Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.
- University of Alberta Canada
Viral Structural Proteins, Genes, Viral, Sequence Homology, Amino Acid, Molecular Sequence Data, Restriction Mapping, Myxoma virus, In Vitro Techniques, Interferon-gamma, Viral Proteins, Viral Interference, Animals, Amino Acid Sequence, Rabbits, Cloning, Molecular, Sequence Alignment, Cells, Cultured, Protein Binding, Receptors, Interferon
Viral Structural Proteins, Genes, Viral, Sequence Homology, Amino Acid, Molecular Sequence Data, Restriction Mapping, Myxoma virus, In Vitro Techniques, Interferon-gamma, Viral Proteins, Viral Interference, Animals, Amino Acid Sequence, Rabbits, Cloning, Molecular, Sequence Alignment, Cells, Cultured, Protein Binding, Receptors, Interferon
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