Glutamine Synthetase: Glial Localization in Brain

descriptionPublicationkeyboard_double_arrow_right Article 25 Mar 1977 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 195, pages 1,356-1,358 (issn: 0036-8075, eissn: 1095-9203,

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Authors: A, Martinez-Hernandez; K P, Bell; M D, Norenberg;

doi: 10.1126/science.14400

pmid: 14400

Glutamine Synthetase: Glial Localization in Brain

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Abstract

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain.

Related Organizations

University of Colorado System
United States
Denver Health Medical Center
United States
University of Colorado Boulder
United States

Keywords

Immunoenzyme Techniques, Glutamates, Ammonia, Glutamate-Ammonia Ligase, Animals, Brain, Neuroglia, gamma-Aminobutyric Acid, Rats

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