Programmed Death of T Cells in HIV-1 Infection
Copyright policy )Programmed Death of T Cells in HIV-1 Infection
In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4 + and CD8 + T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.
- University of Amsterdam Netherlands
CD4-Positive T-Lymphocytes, Male, Acquired Immunodeficiency Syndrome, Cell Death, CD8 Antigens, T-Lymphocytes, HIV Envelope Protein gp120, Microscopy, Electron, Zinc, Antigens, CD, HIV-1, Humans, Cell Division, Cells, Cultured
CD4-Positive T-Lymphocytes, Male, Acquired Immunodeficiency Syndrome, Cell Death, CD8 Antigens, T-Lymphocytes, HIV Envelope Protein gp120, Microscopy, Electron, Zinc, Antigens, CD, HIV-1, Humans, Cell Division, Cells, Cultured
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).1K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!