Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Copyright policy )Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Immune cells and bugs make a sugary coat Epithelial cells line the intestinal tract and help to keep the peace between our immune system and our trillions of gut microbes. Such peacekeeping requires glycosylated proteins (proteins with attached carbohydrate chains) present on the epithelial cell surface, but how glycosylation occurs is unclear. Goto et al. find that fucosylation (a type of glycosylation) of gut epithelial cells in mice requires gut microbes (see the Perspective by Hooper). This process also requires innate lymphoid cells there, which produce the cytokines interleukin-22 and lymphotoxin, presumably in response to microbial signals. These cytokines signal epithelial cells to add fucose to membrane proteins, which allows the détente between microbes and immune cells to continue. Science , this issue 10.1126/science.1254009 ; see also p. 1248
- Ludwig Cancer Research Belgium
- Osaka University Japan
- University of Zurich Switzerland
- University of Michigan–Flint United States
- University of Tokyo Japan
Salmonella typhimurium, Paneth Cells, Glycosylation, Molecular Sequence Data, 610 Medicine & health, 10263 Institute of Experimental Immunology, Mice, Ileum, Animals, Germ-Free Life, Lymphocytes, Intestinal Mucosa, Fucose, 1000 Multidisciplinary, Mice, Inbred BALB C, Base Sequence, Interleukins, Microbiota, Fucosyltransferases, Immunity, Innate, Mice, Mutant Strains, Mice, Inbred C57BL, Disease Models, Animal, Salmonella Infections, 570 Life sciences; biology, Goblet Cells
Salmonella typhimurium, Paneth Cells, Glycosylation, Molecular Sequence Data, 610 Medicine & health, 10263 Institute of Experimental Immunology, Mice, Ileum, Animals, Germ-Free Life, Lymphocytes, Intestinal Mucosa, Fucose, 1000 Multidisciplinary, Mice, Inbred BALB C, Base Sequence, Interleukins, Microbiota, Fucosyltransferases, Immunity, Innate, Mice, Mutant Strains, Mice, Inbred C57BL, Disease Models, Animal, Salmonella Infections, 570 Life sciences; biology, Goblet Cells
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