
pmid: 23539178
Biological Transistor A transistor is a device that amplifies and switches electronic signals. Bonnet et al. (p. 599 , published online 28 March; see the Perspective by Benenson ) engineered a genetic circuit to behave like a transistor in individual living cells. Instead of regulating messenger RNA levels, which has been used previously in designing such systems, the approach relied on changing the state of double-stranded DNA. Six basic logic gates were designed and constructed that were based on the activity of two serine recombinases.
DNA, Bacterial, Recombination, Genetic, Integrases, Transcription, Genetic, Logic, Sequence Inversion, Molecular Sequence Data, DNA-Directed RNA Polymerases, Transcription Termination, Genetic, Escherichia coli, Gene Regulatory Networks, Genetic Engineering, Promoter Regions, Genetic, Bacteriophage M13, Plasmids, Sequence Deletion
DNA, Bacterial, Recombination, Genetic, Integrases, Transcription, Genetic, Logic, Sequence Inversion, Molecular Sequence Data, DNA-Directed RNA Polymerases, Transcription Termination, Genetic, Escherichia coli, Gene Regulatory Networks, Genetic Engineering, Promoter Regions, Genetic, Bacteriophage M13, Plasmids, Sequence Deletion
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