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Article . 2013 . Peer-reviewed
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Article . 2013
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Amplifying Genetic Logic Gates

Authors: Pakpoom Subsoontorn; Peter Yin; Drew Endy; Monica E. Ortiz; Jerome Bonnet;

Amplifying Genetic Logic Gates

Abstract

Biological Transistor A transistor is a device that amplifies and switches electronic signals. Bonnet et al. (p. 599 , published online 28 March; see the Perspective by Benenson ) engineered a genetic circuit to behave like a transistor in individual living cells. Instead of regulating messenger RNA levels, which has been used previously in designing such systems, the approach relied on changing the state of double-stranded DNA. Six basic logic gates were designed and constructed that were based on the activity of two serine recombinases.

Related Organizations
Keywords

DNA, Bacterial, Recombination, Genetic, Integrases, Transcription, Genetic, Logic, Sequence Inversion, Molecular Sequence Data, DNA-Directed RNA Polymerases, Transcription Termination, Genetic, Escherichia coli, Gene Regulatory Networks, Genetic Engineering, Promoter Regions, Genetic, Bacteriophage M13, Plasmids, Sequence Deletion

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    436
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 0.1%
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
436
Top 1%
Top 1%
Top 0.1%
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