RNA-Guided Human Genome Engineering via Cas9
Copyright policy )RNA-Guided Human Genome Engineering via Cas9
Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and plasmid DNA is targeted for cleavage by complementary CRISPR RNAs (crRNAs) bound to a CRISPR-associated endonuclease (see the Perspective by van der Oost ). Cong et al. (p. 819 , published online 3 January) and Mali et al. (p. 823 , published online 3 January) adapted this defense system to function as a genome editing tool in eukaryotic cells.
- Boston University United States
- Wyss Institute for Biologically Inspired Engineering United States
- Harvard University United States
- Universitat Pompeu Fabra Spain
- Boston College United States
Genome, Human, Induced Pluripotent Stem Cells, Inverted Repeat Sequences, Exons, Genoma humà, Genetic Loci, Gene Targeting, Enginyeria genètica, Humans, RNA, Clustered Regularly Interspaced Short Palindromic Repeats, DNA Cleavage, Codon, Genetic Engineering, K562 Cells, Chromosomes, Human, Pair 19
Genome, Human, Induced Pluripotent Stem Cells, Inverted Repeat Sequences, Exons, Genoma humà, Genetic Loci, Gene Targeting, Enginyeria genètica, Humans, RNA, Clustered Regularly Interspaced Short Palindromic Repeats, DNA Cleavage, Codon, Genetic Engineering, K562 Cells, Chromosomes, Human, Pair 19
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